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In accordance, Fe-S clusters are also highly sensitive to oxidation and can be very easily altered in vivo by different drugs, either directly or indirectly due to catabolic by-products, such as nitric oxide species (NOS) or reactive oxygen species (ROS)

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El mecanismo fisiopatológico del HCN se basa en su alta afinidad por iones metálicos, como el Fe 3+ o el Co 3+ , que le lleva a unirse e inactivar enzimas cruciales para el funcionamiento del organismo