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In support of the role of betaine and choline in protecting against hepatocellular carcinoma, Lupu et al., [173] reported that, in a mouse model, the deletion of betaine-homocysteine methyltransferase gene, which is implicated in choline metabolism resulted in the spontaneous elevation of S-adenosylhomocysteine levels and development of preneoplastic foci in the liver
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In addition to physiological changes that occur with aging, and also social risk factors, the elderly population is at a risk for protein malnutrition and vitamin deficiency