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Glia—astrocytes, microglia, and oligodendrocytes—are not passive supporters but active regulators of neuronal survival and function

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Multiple reviews and meta-analyses show that berberine supplementation can modestly improve fasting glucose, HbA1c, and other cardiometabolic markers across diverse adult populations.64 65 While its effects are not dramatic, they’re repeatable and biologically plausible, which is why berberine is often discussed alongside diet and lifestyle strategies for metabolic risk