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In a dehydrogenation reaction where the substrate is oxidized, the oxidized form of the coenzyme (NAD + ) accepts a hydride ion (:H - ) and becomes reduced
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Besides this molecular cross-talk, accumulating evidence suggests that glucocorticoids might play a fundamental role in the entrainment of wake-sleep cycle rhythmicity through regulation of behavioral adaptation to phase shifts, possibly through an indirect feedback to the SCN (44, 59)
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