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In the AVPV, estrogen-ERα complexes, which are highly recruited at the Kiss1 promoter, are likely involved in the histone acetylation of the Kiss1 promoter and the subsequent Kiss1 expression by a chromatin loop formation between the Kiss1 promoter and the 3′-downstream enhancer region [68]

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Color:Purple / Silver - Velvet

Both compounds would benefit significantly from independent replication, chronic safety studies, and -- if warranted by safety data -- carefully designed early human studies