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This is clinically significant, particularly in severely ill patients who have undergone massive transfusions and infants under four months old, as they have a reduced ability to replenish their 2,3-DPG levels and compensate for hypoxemia and its effects (Reference Högman, Löf and Meryman73,Reference Weisberg, Vossoughi and Barbeau74)

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doi: 10.4321/s0004-06142005000900010