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Krüppel-like factor 4(KLF4) can regulate phenotypic transformation and regulates inflammatory response and proliferation of VSMC during cardiovascular remodeling ( In vivo studies, TanⅡA (10 mg/kg/d) can reduce vascular inflammation and intimal hyperplasia induced by carotid artery ligation in C57BL/6 mice by inhibiting the expression of miR-712-5p (Qin et al., 2020)
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Combining dietary interventions with lifestyle modifications, such as regular physical activity and smoking cessation can enhance mitochondrial function and improve overall lung health
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