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doi: 10.1016/j.xplc.2026.101875

Gastrointestinal Conditions

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Strong colocalization between xCT and AQP5, as measured by Pearson’s Correlation Coefficient and Manders’ Coefficients, indicated ART’s role in mitigating ferroptosis and restoring salivary secretion capacity ( Figures 7E, F ).ART inhibits KEAP1-mediated ubiquitination and degradation of NRF2, activating NRF2-regulated antioxidant gene expression and rescuing SGECs from ferroptosis