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Consequently, it cannot establish causality for ICI-related irAEs

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Gonadotropin levels (FSH/LH) that are NOT excessively high (the medications work by increasing FSH and LH - if they are already high, making them higher usually will not help) + Clomid (Clomiphene Citrate) 50 mg every 1-2 days Mechanism : 'Selective Estrogen Receptor Modulator (SERM)' - blocks the negative feedback of estradiol on the pituitary such that gonadotropins (FSH and LH) are increased