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Among all the metabolites and the parent compound, NAPQI has also the lowest solvation energy, meaning it would be least soluble in water
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On a cautionary note regarding the use of NAC as an antagonist to assess isothiocyanate-induced ROS-mediated apoptosis, the investigators indicated that NAC pretreatment significantly inhibited the cellular uptake of isothiocyanates by conjugating with them in the medium [36]
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