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The importance of GSH as a cellular redox buffer is underscored by the fact that GSH displays a low redox potential (E' 0 = −240 mV) and is found in high concentration in the cells (∼10–15 m M ) (52, 72, 95)

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The genes associated with DFNA5, a noncomprehensive sensorineural deafness that is very similar to ARHL, are all likely genetic factors for ARHL (Wang and Puel, 2020