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A 2025 Frontiers in Genetics review on precision skin care names the leads: COL1A1 and COL3A1 (how much structural collagen you build), ELN (elastin), SOD2 (antioxidant defense against UV and pollution), and—the pivotal one here—MMP1, the collagenase that initiates collagen breakdown.26 The well-studied MMP1 promoter variant (the −1607 1G/2G polymorphism) creates an extra transcription-factor binding site in 2G carriers, raising MMP1 output