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The characteristic phenotype of TFH cells includes the expression of C-X-C chemokine receptor type 5 (CXCR5), induced T cell costimulator (ICOS), programmed cell death protein 1 (PD-1), B-cell lymphoma 6 (Bcl-6), and interleukin-21 (IL-21), which are integral to regulating the differentiation of TFH cells and the formation of GCs (139)