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Previously studies have shown that ROS induced phosphorylation of p53 protein is mediated via protein kinases, including ATM, ERK, p38 MAPK and JNK [50]
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Interestingly, succinate supplementation also phenocopied decreased αKG in its ability to inhibit proliferation of CCNE1-driven cells in the presence of DNA damaging agents and was rescued by αKG supplementation ( Fig
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