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Exosomal miR-21-3p from nicotine-treated macrophages may speed up atherosclerosis by promoting VSMC migration and proliferation via phosphatase and tension homologue [127]

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What it transports: ✓ Methylfolate (nature's preferred form) ✓ Folinic acid (therapeutic form) ✗ Folic acid (BLOCKS this pathway) Transport #2: Proton-Coupled Folate Transporter (PCFT) — Supporting Route (10-20%) PCFT handles 10-20% of transport and becomes critical when FRα is impaired