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A particular role is played by the functional single nucleotide polymorphism (SNP) in the BDNF gene, which consists of the substitution of adenine by guanine (A/G) at position 196 in exon 5 of the BDNF gene, resulting in the replacement of the amino acid valine (Val) by methionine (Met) in codon 66 (Val66Met, also known as Rs6265) [5,38]

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Moderate: Results from multiple animal studies but requiring more replication or mechanistic data