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Researchers still don’t understand the exact mechanism behind this process, but we do know that when patients have stopped these supplements their acne has improved

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A 2018 review in the International Journal of Molecular Sciences compiled transcriptome-profiling data showing thousands of human genes flagged as up- or down-regulated under GHK-Cu exposure across multiple cell-type studies, framing the compound's pleiotropy at the regulatory-network level (PMID 29986520)