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(Some researchers believe that this is the primary therapeutic form of the drug because of its long persistence in the brain compared to fluoxetine.) Using the data from the Sunnybrook website [1] and taking the half-life to be 9 days for norfluoxetine, a reasonable model using linear kinetics for the blood plasma concentration of norfluoxetine is given by the equation N ( t ) = 27.5( e - 0.077 t - e - 0.462 t )

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doi: 10.1007/s00216-013-6900-7

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