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This process, known as osteoarthritis, can lead to: persistent stiffness pain during walking reduced mobility swelling after activity difficulty climbing stairs progressive loss of joint function Although osteoarthritis is often associated with aging, previous injuries, excess body weight, genetics, and occupational demands can all contribute to its development
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To address the issue, western blotting analysis was further performed to confirm that there were obvious decreased level of 4-HNE in LA-treated mice, compared with FA-injected ones, but no significant difference between the high- and low-dose groups was observed, as shown in Figure 5
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