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In this process, transporters act more like receptors, facilitating the internalization of the NPs into the endothelial cells via endocytosis, after which the NPs are released into the brain via exocytosis

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In the case of the developed IGF-1 MSIA-SRM, the use of the MSIA tips in comparison to beads translated into a 10-fold lower limit of detection and a 20-fold LLOQ for an extraction method requiring less than 30 minutes