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Th2 response is triggered by Th2 cells activation, IL-4, IL-5, IL-13 release, as well as eosinophil promotion, and subsequent IgE production (272, 276–278), whereas Treg cells shift the response toward immunosuppressive phenotype through IL-10 and TGF-β cytokines, which may be induced directly by the helminth or through the microbiome (279, 280)