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Underlying pathologies (such as sepsis, hepatic impairment, and renal dysfunction) can induce anemia of inflammation, a condition driven by proinflammatory cytokines (including IL-1, IL-6, TNF-α, and IFN-γ) and characterized by impaired iron utilization and suppressed erythropoiesis ( Concurrently, recurrent iatrogenic interventions–such as diagnostic phlebotomy and the utilization of extracorporeal circuits (e.g., CRRT, ECMO) ( Chronic anemia, frequently referred to as anemia of inflammation, predominantly arises from persistent inflammatory states, chronic kidney disease, or other underlying pathologies ( While blood loss and chronic inflammation remain the predominant etiologies, clinicians must maintain vigilance regarding drug-induced anemia–specifically drug-induced hemolytic anemia (DIHA) (Table 1)
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Prev Sci 2007