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Adiponectin or activation of adiponectin receptor 1 (AdipoR1) can upregulate multiple hair growth factors through AMP-activated protein kinase (AMPK) in human follicular DPC, including IGF-1, vascular endothelial growth factor (VEGF), IGF, HGF, PDGFA, and FGF 7, and downregulate TGFβ1, thereby inducing the anagen and promoting hair growth ex vivo and in vivo 100 - 103

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