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One of the main effects of MPO and its final product, hypochlorous acid (HOCl), is the formation of free radicals, such as chloramines that are involved in oxidative damage and pro-inflammatory responses ( TNF-ฮฑ plays an important role in the development of ulcerative lesions when initiating an acute inflammatory response, accompanied by neutrophilic infiltration in the gastric mucosa ( Treatment with (-)-Carveol reduced the levels of pro-inflammatory cytokines (TNF-ฮฑ and IL-1ฮฒ) and increased the regulatory cytokine IL-10 back to baseline levels, suggesting an interesting immunomodulatory effect