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At this point, test subjects can either be administered lower doses of the CJC-1295 peptide, or the research can be discontinued

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Briefly, wild-type (wt, 5′-GAGTGTGGATGACCCTTGGT-3′) or mutant (mut, 5′-CTCACACCTACTGGGAACCA-3′) sequence in MBOAT1 promoter region or wt (5′-GGTAAAGAGGCGCGGGGA-3′) or mut (5′-CCATTTCTCCGCGCCCCT-3′) sequence in METTL1 promoter region was fused into luciferase pGL3-basic reporter vector (Promega, Madison, USA) to construct pmirGLO-MBOAT1-wt/-mut or pmirGLO- METTL1 -wt/-mut (sequences in Supplementary Table S6)