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DSIP was first characterized by Marcel Monnier and colleagues at the University of Basel, Switzerland, arising from a series of cross-circulation experiments in which blood from a sleeping rabbit was transferred to an awake recipient, causing measurable changes in the recipient's EEG brainwave patterns consistent with delta-wave sleep induction
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However, the prevailing evidence predominantly points toward caspases, Bcl-2, and p53 as integral components of the pathways underlying neuronal cell death induced by epileptic seizures [38]
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