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[1] This reflux could theoretically result in a bitter or metallic taste in the mouth, particularly when lying down or after meals, though this connection requires further study

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Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R