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While gut microbiota depletion in control mice resulted in improved glucose tolerance, this effect was fully reversed upon a whole-body knockdown of the GLP-1 receptor ( Figures 2E, F ), suggesting that GLP-1 signaling is essential for the observed glucose tolerance improvement

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In the absence of a definitive composition, he suggested that “provisionally, for easy reference, the name glutathione will perhaps be admissible” (Hopkins, 1921)