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Consequences of ROS formation depend on the combination of the following factors: intensity of stress and physicochemical cell conditions, i.e., antioxidant status, integrity of membranes, energy resources and redox state ( GSH is one of the major non-enzymatic tissue antioxidants and detoxifying agents additionally involved in xenobiotics removal ( 2 O 2 to H 2 O with formation of disulfide bonds between two GSH molecules, that gives rise to GSSG – oxidized glutathion
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α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokers
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