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Considering the growing significance of macrocyclic peptides as research tools and potential therapeutic agents, peptide drug-screening methods like phage display, 342,343 mRNA display, 344,345 and split-intein circular ligation of peptides and proteins (SICLOPPS) 346 (Figure 15) gradually advance, the process of encoding diverse peptide libraries for discovery of bioactive macrocycles has also become increasingly convenient
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