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This advanced ribosome variant demonstrated a remarkable 58% increase in activity in orthogonal protein translation and successfully improved the incorporation efficiency of the noncanonical l-α-amino acid (( R )-2-amino-3-(7-(diethylamino)-2-oxo-2 H -chromene-3-carboxamido)propanoic acid, DECP) with the help of flexizyme charging DECP onto tRNA fMet CAU