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Medical misuse includes prescribing androgens for male infertility (471) or sexual dysfunction in men without androgen deficiency (423) where there are no likely benefits or as a tonic for non-specific symptoms in older men (“male menopause”, ‘andropause”, “late-onset hypogonadism”) (426) or women (368) where safe and effective use is unproven

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APAP overdose not only depletes mitochondrial GSH levels, induces formation of peroxynitrite in mitochondria (57), moreover it causes intracellular Ca 2+ accumulation