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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance (80)

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Foods rich in monounsaturated fatty acids have been shown to facilitate its uptake, whereas excessive intake of polyunsaturated long-chain fatty acids or dietary fiber may inhibit absorption [80].Although oral intake alone typically accounts for only 10–20% of the body’s Vitamin D requirements, dietary supplementation remains an important non-pharmacological intervention for individuals with limited sun exposure or impaired cutaneous synthesis [81]