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Mice were housed in specific pathogen-free conditions with a 12: 12 h light/dark cycle with a temperature of 24 °C ± 0.5 °C and a relative humidity of 40%-70%

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448 In the study of OTUD3, computer‐aided virtual screening and biological experiments identified two OTUD3 inhibitors, OTUDin3 and Rolapitant, which inhibit the deubiquitinase activity of OTUD3