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As the most abundant free amino acid in circulation, it serves as a major metabolic substrate for rapidly proliferating immune cells, sustains intestinal barrier integrity, assists in nitrogen transport, and contributes to acid–base homeostasis (Newsholme, 2001)

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The slight PDI elevation witnessed at the later time points (day 42 and day 56) is indicative of the inherent challenges associated with long-term storage of complex multimodal nanocarrier systems