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Persistent smokers may, in that case, inhale more ROS than can be scavenged by the residual antioxidants, resulting in increased vulnerability to oxidative stress

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The bacterial metabolite indolepropionic acid (IPA), derived from tryptophan metabolism, exerts cytostatic effects on metastatic breast cancer cells, that is, it inhibits cancer cell proliferation and movement, decreases epithelial-to-mesenchymal transition, and enhances ROS production and lymphocyte infiltration into the tumor without harming non-cancerous cells surrounding the tumors (263)