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In a recent randomized, placebo-controlled trial conducted to investigate the effect of NAC and working memory-training to reduce cocaine use and craving and to improve inhibition, a 25-day treatment with NAC (2.4 g/day) was associated with fewer cocaine problems and cocaine-positive urines compared with placebo [129]

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Yak1p activity appeared to be mediated by its kinase activity as its effect was lost when a kinase dead (KD) form p.K398R of YAK1 (Moriya et al., 2001) was used (Figure 1D)