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After consideration of public comments, we are finalizing as proposed changes to the definition of a “beneficiary eligible for Medicare CQMs” at § 425.20, effective January 1, 2025
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or wild-type patients or DPYD carriers without a genotype-guided fluoropyrimidine dose reduction Excluded: patients who received treatment with uridine triacetate Fluoropyrimidine Treatment Effectiveness Intervention Included: carriers of at least one of the variants under assessment, with DPYD -genotyping-guided fluoropyrimidine dose adjustment before the start of treatment Excluded: patients with no fluoropyrimidine dose adjustment before the start of treatment