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For example, one study reported that polymeric nanoparticles assembled from chitosan (CS) and polyaspartic acid (PAA) can deliver EGCG , which reduces the area of rabbit aorta occupied by lipid deposits ( ferulic acid is a natural antioxidant reported to reduce macrophage adipogenesis, these ferulic acid–based NPs downregulated CD36 and LOX-1 expression in macrophages and inhibited macrophage uptake of oxidized low-density lipoprotein (ox-LDL)
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