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A third model incorporated both APOE and AD diagnosis (or Aβ status) as independent variables to account for the confounding effect of the APOE –AD or APOE –Aβ association: Model type 1: Protein = β1 + β2 APOE + covariates + ϵ Model type 2: Protein = β3 + β4 AD diagnosis (or Aβ) + covariates + ϵ Model type 3: Protein = β5 + β6 APOE + β7 AD diagnosis (or Aβ) + covariates + ϵ Covariates included age, sex, and mean overall protein level in all cohorts, with study cohort additionally included as a covariate for the GNPC dataset
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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, et al