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In the CY 2026 PFS proposed rule (90 FR 32678), we stated that we believe that the use of flat benchmarks in a measure's first two performance periods in MIPS may allow ACOs with high scores to earn maximum or near maximum measure achievement points while allowing room for quality improvement and rewarding that improvement in subsequent years

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This is in fact a central tenet of the ability of Fur proteins to orchestrate a graded response to increasing degrees of cellular metal limitation, where differentially metal-ligated states differentially repress the expression of downstream genes as metal levels incrementally fall in the cell