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23,24 Although the importance of necroptosis, pyroptosis, and ferroptosis in APAP-induced liver injury has been questioned, 25,26 ferroptosis has emerged as a favored mode of cell death, with a dramatic increase in related publications in recent years
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In studies of their reactions with DNA, each diol epoxide became bound covalently to DNA and showed a unique product distribution, with either a preference for reaction with deoxyadenosine residues or a more even distribution between deoxyguanosine and deoxyadenosine residues
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