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However, what is less recognized is that the original erastin-mediated ferroptosis induced a mitochondria-independent oxidant stress, causing cell death, did not trigger cellular ATP depletion, and the morphology of the mitochondria indicates that they are smaller and denser, not swollen as is generally observed during necrotic cell death [13]

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Many vets advise that this can be done without anesthetic, because the procedure is so quick with little pain