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A comprehensive literature search was performed across six major electronic databases: PubMed, Scopus, Web of Science, Embase, Google Scholar, and Cochrane Library
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However, much like with aminorex, it was soon observed that patients being treated with fenfluramine were at risk for developing pulmonary hypertension and, of even greater concern, valvular heart disease, causing both fenfluramine and its derivative dexfenfluramine to be withdrawn from the market in 1997
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