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Metal-based drugs therefore appear to have considerable potential as novel therapeutic agents against cancer because they display wide chemical diversity and versatility, exist in different oxidation states, coordinate diverse types of ligands, exhibit redox activity, and react with important biomolecules in cells, such as proteins or DNA
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[1] Lower doses (10-20 mg/kg) are employed when studying subtle DNA repair mechanisms, while higher doses (35-45 mg/kg) are used to evaluate robust cellular responses to DNA damage and senescence induction
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