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Although H 2 regulates the expression of various genes and protein activation states, it remains to be determined whether such modulations are the cause or result of the physiological effects of H 2

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Perturbations of this axis, such as oral dysbiosis or compromised barrier function, have been increasingly implicated in the pathogenesis of diverse systemic diseases, which involve three key mechanistic pathways of how localized oral events could exert distant effects ( Table 1 )