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Once reconstituted, IGF-1 LR3 remains stable for 14 days at 2–8°C

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Most patients with knee cartilage injuries are appropriate candidates for a nonsurgical approach, particularly those who: Have early-to-moderate cartilage damage confirmed on imaging Have persistent symptoms despite conservative care (exercise, PT, weight management) Wish to avoid or delay surgery Have no active infection, malignancy, or severe structural instability requiring surgical decompression Nonsurgical approaches are generally not appropriate for patients with advanced bone on bone changes, progressive neurological symptoms, or conditions where decompression or structural reconstruction cannot be deferred