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We used 48 h as cut-off value for evaluating the laboratory data, because it is not known how fast the 5-oxoproline levels and the other measured laboratory values change to normal levels after discontinuation of the drugs

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Research indicates that most of the intravenously administered EXOs are quickly removed from circulation by the mononuclear phagocyte system in a matter of minutes, thus reducing their therapeutic range (Honda et al., 2025)