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(I see this in thousands of our patients) Waking between 3–5am with difficulty returning to sleep is classic sleep maintenance insomnia, and in fathers/middle-aged men it’s usually multifactorial: 1) Cortisol & the Early Morning Surge Cortisol naturally rises around 3–4am to prepare the body to wake

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A desthiobiotin labelled NAD(+) analogue to uncover Poly(ADP-ribose) polymerase 1… [PMID: 38236015] Laboratory literature summary: A desthiobiotin labelled NAD(+) analogue to uncover Poly(ADP-ribose) polymerase 1 protein targets