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Nrf2 is a key transcription factor that plays an important role in the maintenance of oxidative balance by regulating the activity of a variety of antioxidant enzymes in the cellular defense system, such as SOD, GSH-Px, and CAT (Amaral et al

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Moreover, data showing increased motor-cortex excitability in women with PMS 65 may suggest that inhibitory neurotransmission is overall reduced in this disorder